Dynamic ion-ion and water-ion interactions in ion channels
نویسندگان
چکیده
منابع مشابه
O 13: Ion Channels in Autoimmune Neurodegeneration
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
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In this paper, the photochemical degradation of azure-b by Cu2+/S2O82− process has beenpresented. Cu2+ as photocatalyst and S2O82− ion as photooxidant used in this process. Atextremely low concentrations, cupric ion showed true catalytic activity in the overall process.The influence of various parameters on the performance of the treatment process has beenconsidered, such as pH, concentration o...
متن کاملo 13: ion channels in autoimmune neurodegeneration
multiple sclerosis (ms) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. ionic conductances regulate t cell activation as well as neuronal function and thus have been found to play a crucial role in ms pathogenesis. since present therapeutical approaches are only parti...
متن کاملIon Channels
Ion channels catalyze the transmembrane movement of small inorganic ions across biological membranes. They do so by forming continuous, hydrophilic pores through which ions can cross the barrier imposed by the lipid bilayer hydrophobic core. Ion channels serve many functions: they underlie the changes in membrane potential that control many cell functions, including the propagated electrical si...
متن کاملIon–Ion Interactions at the Selectivity Filter
In the Kv2.1 potassium channel, binding of K(+) to a high-affinity site associated with the selectivity filter modulates channel sensitivity to external TEA. In channels carrying Na(+) current, K(+) interacts with the TEA modulation site at concentrations </=30 microM. In this paper, we further characterized the TEA modulation site and examined how varying K(+) occupancy of the pore influenced ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1992
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(92)81940-9